%0 Journal Article
%@ 2369-6893
%I JMIR Publications
%V 4
%N 1
%P e10539
%T The Growing Antimicrobial Resistance of Urinary Tract Infections, Sana'a- Yemen, 2015
%A Ghaleb,Yasser
%A Al Serouri,A
%A Alamad,M
%A Nasher,S
%A Alsoumainy,A
%D 2018
%7 29.03.2018
%9 Abstract
%J iproc
%G English
%X Background: Urinary tract infections (UTIs) remain a growing public health concern as it may lead to treatment failure and increasing morbidity and mortality. To optimize empirical antibiotic prescription, it is important for clinicians to have a working knowledge regarding UTIs etiological pathogens and its susceptibility patterns. Objective: Determine the prevalence of UTIs, describe their responsible pathogens, and their antimicrobial resistance. Methods: 2015 data on patients attended the Microbiology Department in National Centre for Public Health laboratories (NCPHL) for urine cultures was obtained. UTIs defined as =100,000 CFU/mL of an uropathogen in midstream urine culture. The causative pathogen was identified, and antibiotic resistance carried out by disc-diffusion method. Results: Out of 2901 patients examined, 58% were females and half among 20-40 years age group. The prevalence of UTIs was 34% and more among females: Odds Ratio (OR): 1.8 (1.5-2.0) and elderly = 60 years (OR: 1.4 (1.1-1.8). Gram-negative bacteria constitute 73% of UTI and found to be highly resistance to Nalidixic acid (70%), Co-trimoxazole (64%), and Piperacillin (62%). Gram-positive bacteria that constitutes 27 % found to be highly resistant to Co-trimoxazole (81%), Norfloxacin (69%) and Amoxicillin (67%). E. coli was the most common pathogen (42%), followed by coagulase negative Staphylococci (10%) and Klebsiella (8%). While E. coli found to be resistant to Co-trimoxazole (66%) and Nalidixic acid (71%), Klebsiella was resistant to Co-trimoxazole (88%) and Nalidixic acid (64%), and Coagulase Negative Staphylococci to Co-trimoxazole (88%) and Amoxicillin (75%). Conclusions: Findings highlight the doubling of UTIs prevalence and growing antibiotics resistance e.g. for Nalidixic acid from 54% to 70% since 2002. Results should guide antibiotic prescribing and developing strategies for controlling resistance. It also underlines the need to establish Antimicrobial Stewardship Program to reduce selection pressure and minimize resistance. 
%R 10.2196/10539
%U http://www.iproc.org/2018/1/e10539/
%U https://doi.org/10.2196/10539