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EMPHNET 7th Regional Conference 2021: “Towards Public Health Resilience in the EMR: Breaking Barriers” (62)

Published on in Vol 8, No 1 (2022): Jan-Dec

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/36557, first published .
Prevalence of and Factors Associated With Transfusion-Transmitted Infections Among Multi-transfused Patients, Sana'a City, Yemen, 2019

Prevalence of and Factors Associated With Transfusion-Transmitted Infections Among Multi-transfused Patients, Sana'a City, Yemen, 2019

Prevalence of and Factors Associated With Transfusion-Transmitted Infections Among Multi-transfused Patients, Sana'a City, Yemen, 2019

Authors of this article:

Suaad Moghalles1 Author Orcid Image ;   Abdulwahed Al Serori1 ;   Abd Alrahman Alhadi2 ;   Ahmed Shamsan3
Article Authors Cited by Tweetations Metrics

    Abstract

    1Yemen-FETP, Sana'a, Yemen

    2Leukemia Childhood Unit, Sana'a, Yemen

    3Thalassemia & Genetic Blood Disorder Association, Sana'a, Yemen

    Corresponding Author:

    Suaad Moghalles

    Yemen-FETP

    Building 24, Hadah

    Sana'a, 00967

    Yemen

    Phone: 967 735800572

    Email: smughalles@gmail.com


    Background: Multi-transfused patients (MTPs) are at higher risk of transfusion-transmitted infections (TTIs) due to their frequent need for blood transfusion. Nevertheless, little is known about the prevalence of TTIs among MTPs and its associated factors in Yemen.

    Objective: We aimed to determine the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV and its associated factors among MTPs.

    Methods: A cross-sectional study was conducted at the Yemeni Society for Thalassemia and at Pediatric Leukemia Unit in Sana’a City. The calculated sample size of 357 was increased to 405 to overcome any nonresponses. By using probability proportional to size sampling, 80 patients with thalassemia, 240 patients with sickle cell anemia, and 85 patients with leukemia were randomly selected. Data were collected through face-to-face interviews with patients or their caretakers by using a predesigned questionnaire covering demographic, socioeconomic characteristics and TTI-associated factors. Blood samples were drawn and were tested for HBsAg, anti-HCV, and HIV I and II by using an electrochemiluminescence immunoassay.

    Results: The overall prevalence of TTIs among MTPs was 13.1% and was significantly highest (37.3%) among patients with leukemia. HBV (16.2%) and HCV (27.5%) prevalence were also highest among patients with leukemia. Only 2 (0.04%) patients were found to be HIV positive among patients with sickle cell anemia. Coinfection with HBV and HCV was only found in 5 patients with leukemia. There was a significant association between TTIs and the receipt of >30 blood units. Only 35% of MTPs were found to be vaccinated against HBV.

    Conclusions: Our findings raise an alarm for the existence of a high risk of TTIs among MTPs, especially among patients with leukemia and those who undergo an increasing number of transfusions. Using advanced technology in blood screening and strict infection prevention during transfusion should be adopted. The rational use of blood/blood substitutes and ensuring that MTPs are vaccinated against HBV are recommended.

    iproc 2022;8(1):e36557

    doi:10.2196/36557

    Keywords

    prevalence; transfusion-transmitted infections; multi-transfused patients; Yemen 

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    Multimedia Appendix 1

    Prevalence and factors associated with transfusion-transmitted viral infections among multi–transfused patients, Sana'a City, Yemen, 2019.

    PPTX File , 445 KB

    Edited by Y Khader; This is a non–peer-reviewed article. submitted 17.01.22; accepted 18.01.22; published 15.03.22

    Copyright

    ©Suaad Moghalles, Abdulwahed Al Serori, Abd Alrahman Alhadi, Ahmed Shamsan. Originally published in Iproceedings (https://www.iproc.org), 15.03.2022.

    This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in Iproceedings, is properly cited. The complete bibliographic information, a link to the original publication on https://www.iproc.org/, as well as this copyright and license information must be included.